Hugely popular Mozilla community providing support for Firefox, Thunderbird, Seamonkey and other well known Mozilla products. Over 350k members and 4 Million posts.
Conquer Club is an online multiplayer world domination game. The discussion forum is host to over 500,000 members and 2.8 million posts.
The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
OpenOffice.org offers a free and fully-featured office suite which meets the needs of the common consumer all the way up to large enterprises.
KDE is mainly known for producing the KDE Desktop Environment (used in Kubuntu) for Linux.
Pixelmator is a popular commercial image editing software for Mac OS X users.