Adblock Plus is one of the most popular Firefox Add-ons in the world, with over 10 Million daily users and over 100k downloads a day. They use phpBB to offer support to their users.
Pixelmator is a popular commercial image editing software for Mac OS X users.
Inspired by Max Berry's book, Jennifer Government, NationStates is one of the most popular online simulation games. The forum boasts over 5 million posts and 200,000 users.
Gentoo Linux is an open source operating system built on top of the Linux kernel and based on the Portage package management system.
Discussion board for the massively popular xkcd web comic. Covering everything from Maths and Science to Logic Puzzles and Forum Games. Over 100k members and 2.4 Million posts.
Official Support Forum for Debian, the kernel-based open source operating system. phpBB provides a solid platform for support and discussion.