Joomla is one of the leading open-source Content Management Systems. With a userbase of over 400,000, they use phpBB as a reliable platform for support.
OpenOffice.org offers a free and fully-featured office suite which meets the needs of the common consumer all the way up to large enterprises.
Inspired by Max Berry's book, Jennifer Government, NationStates is one of the most popular online simulation games. The forum boasts over 5 million posts and 200,000 users.
Discussion board for the massively popular xkcd web comic. Covering everything from Maths and Science to Logic Puzzles and Forum Games. Over 100k members and 2.4 Million posts.
Adblock Plus is one of the most popular Firefox Add-ons in the world, with over 10 Million daily users and over 100k downloads a day. They use phpBB to offer support to their users.
Hugely popular Mozilla community providing support for Firefox, Thunderbird, Seamonkey and other well known Mozilla products. Over 350k members and 4 Million posts.