Pixelmator is a popular commercial image editing software for Mac OS X users.
Discussion board for the massively popular xkcd web comic. Covering everything from Maths and Science to Logic Puzzles and Forum Games. Over 100k members and 2.4 Million posts.
Independent site for Dutch horse lovers. With over 280,000 members and 95 million posts, Bokt.nl is widely acclaimed as one of the largest boards powered by phpBB.
The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
KDE is mainly known for producing the KDE Desktop Environment (used in Kubuntu) for Linux.
Joomla is one of the leading open-source Content Management Systems. With a userbase of over 400,000, they use phpBB as a reliable platform for support.