OpenOffice.org offers a free and fully-featured office suite which meets the needs of the common consumer all the way up to large enterprises.
Pixelmator is a popular commercial image editing software for Mac OS X users.
Adblock Plus is one of the most popular Firefox Add-ons in the world, with over 10 Million daily users and over 100k downloads a day. They use phpBB to offer support to their users.
The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
Inspired by Max Berry's book, Jennifer Government, NationStates is one of the most popular online simulation games. The forum boasts over 5 million posts and 200,000 users.
Boasting almost 14 million posts, Ars Technica is one of the biggest and oldest technical forums still operating today. They use phpBB to power their forums and comment system.