Pixelmator is a popular commercial image editing software for Mac OS X users.
The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
Discussion board for the massively popular xkcd web comic. Covering everything from Maths and Science to Logic Puzzles and Forum Games. Over 100k members and 2.4 Million posts.
Discussion forum for the massively popular American animated sitcom. Powered by phpBB.
OpenCart is popular, powerful, and easy to use shopping cart software. Their healthy community forums are powered by phpBB.
Hugely popular Mozilla community providing support for Firefox, Thunderbird, Seamonkey and other well known Mozilla products. Over 350k members and 4 Million posts.