The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
KDE is mainly known for producing the KDE Desktop Environment (used in Kubuntu) for Linux.
Discussion forum for the massively popular American animated sitcom. Powered by phpBB.
Discussion board for the massively popular xkcd web comic. Covering everything from Maths and Science to Logic Puzzles and Forum Games. Over 100k members and 2.4 Million posts.
Pixelmator is a popular commercial image editing software for Mac OS X users.
Zend Technologies is one of the largest and most popular companies producing a wide variety of tools and frameworks for PHP. Their community forums rely on phpBB.