The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
Zend Technologies is one of the largest and most popular companies producing a wide variety of tools and frameworks for PHP. Their community forums rely on phpBB.
Adblock Plus is one of the most popular Firefox Add-ons in the world, with over 10 Million daily users and over 100k downloads a day. They use phpBB to offer support to their users.
KDE is mainly known for producing the KDE Desktop Environment (used in Kubuntu) for Linux.
Conquer Club is an online multiplayer world domination game. The discussion forum is host to over 500,000 members and 2.8 million posts.
Pixelmator is a popular commercial image editing software for Mac OS X users.