The VideoLAN project produces the extremely popular VLC media player software. Their forums provide support for users of the software as well as the development community.
Inspired by Max Berry's book, Jennifer Government, NationStates is one of the most popular online simulation games. The forum boasts over 5 million posts and 200,000 users.
Joomla is one of the leading open-source Content Management Systems. With a userbase of over 400,000, they use phpBB as a reliable platform for support.
Pixelmator is a popular commercial image editing software for Mac OS X users.
Conquer Club is an online multiplayer world domination game. The discussion forum is host to over 500,000 members and 2.8 million posts.
Adblock Plus is one of the most popular Firefox Add-ons in the world, with over 10 Million daily users and over 100k downloads a day. They use phpBB to offer support to their users.